Coffee Consumption and Prostate Cancer Risk and Progression in the Health Professionals Follow-up Study

Coffee Consumption and Prostate Cancer Risk and Progression in the Health Professionals Follow-up Study. Coffee contains many geologically committed compounds, counting caffeine and phenolic acids, with the intention of be inflicted with heady antioxidant endeavor and can affect glucose metabolism and masculinity hormone levels. Because of these biological activities, coffee could be associated with a cut-rate expose of prostate cancer.

Methods We conducted a prospective analysis of 47 911 men in the Health Professionals Follow-up Study who reported intake of regular and decaffeinated coffee in 1986 and each 4 years thereafter. From 1986 to 2006, 5035 patients with prostate cancer were identified, counting 642 patients with lethal prostate cancers, defined as fatal or metastatic. We used Cox proportional hazards models to assess the friendship linking coffee and prostate cancer, adjusting pro the makings puzzling by smoking, stoutness, and other variables. All P principles were from two-sided tests.

Results The mean intake of coffee in 1986 was 1.9 cups for every time. Men who consumed six or more cups for every time had a decrease adjusted relation expose pro overall prostate cancer compared with nondrinkers (RR = 0.82, 95% confidence interval [CI] = 0.68 to 0.98, Ptrend = .10). The friendship was stronger pro lethal prostate cancer (consumers of more than six cups of coffee for every time: RR = 0.40, 95% CI = 0.22 to 0.75, Ptrend = .03). Coffee consumption was not associated with the expose of nonadvanced or low-grade cancers and was single imperceptibly inversely associated with high-grade cancer. The inverse friendship with lethal cancer was akin pro regular and decaffeinated coffee (each lone cup for every time increment: RR = 0.94, 95% CI = 0.88 to 1.01, P = .08 pro regular coffee and RR = 0.91, 95% CI = 0.83 to 1.00, P = .05 pro decaffeinated coffee). The age-adjusted incidence tariff pro men who had the highest (≥6 cups for every day) and lowest (no coffee) coffee consumption were 425 and 519 whole prostate cancers, correspondingly, for every 100 000 person-years and 34 and 79 lethal prostate cancers, correspondingly, for every 100 000 person-years.

Conclusions We experimental a strong inverse friendship linking coffee consumption and expose of lethal prostate cancer. The friendship appears to be correlated to non-caffeine components of coffee.